On a desolate stretch of desert highway, weary travelers - two men on the run from their past, a band on their way to the next gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation - are forced to confront their worst fears and darkest secrets in a series of interwoven tales of terror and remorse on the open road.

The siblings Hansel and Gretel are left alone in the woods by their father and captured by a dark witch in a candy house. However they kill the witch and escape from the spot. Years later, the orphans have become famous witch hunters. When eleven children go missing in a small village, the Mayor summons Hansel and Gretel to rescue them, and they save the red haired Mina from the local sheriff that wants to burn her accusing Mina of witchcraft. Soon they discover that the Blood Moon will approach...